Dr Hozumi Motohashi

Tohiku Univeristy, Japan

Dr. Hozumi Motohashi received MD/PhD from Tohoku University Graduate School of Medicine, Japan.  Her thesis was on the regulatory mechanism and in vivo function of MafK, one of the small Maf transcription factors.  After the commencement, she was assigned to a research assistant professor at University of Tsukuba.  She worked on the clarification of function and biological significance of CNC-sMaf transcription factors.  After she moved to Tohoku University as an associate professor, she focused on response mechanisms to various internal and external oxidative/xenobiotic stresses and contributions of NRF2, one of the CNC transcription factors, to the maintenance of homeostasis.  She also clarified unique metabolic features of malignant cancers in which NRF2 is aberrantly activated.  She started her own lab in 2013 as a professor at Institute of Development, Aging and Cancer, Tohoku University and launched new projects on anti-aging function of NRF2 and pathophysiological roles of sulfur metabolism regulated by NRF2.  Out of sulfur-containing metabolites, supersulfides, which are defined as molecules that contain sulfur catenation and have been identified as a new entity of biomolecules, are at the center of her current research interest because of their substantial contribution to the NRF2-dependent cytoprotection and other biological processes.  Her lab is focusing on regulatory mechanisms of NRF2-dependent transcription and its contribution to various aging-related diseases, including cancer, inflammation, and degeneration, through regulation of sulfur metabolism.

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