Marnie’s lab focuses on understanding the mechanisms of epigenetic control, and how such mechanisms can be manipulated in the context of disease. She uses functional genetic screens to identify epigenetic regulators, which she started as a PhD student with Emma Whitelaw at The University of Sydney. Marnie took up a NHMRC Post-doctoral fellowship with Doug Hilton WEHI to work on the novel protein SMCHD1 that she identified in her PhD. This work earned her the AAS Gani medal and the L’Oreal Australia Women in Science fellowship 2009. In 2010, Marnie established her own lab at WEHI as an ARC QEII fellow. Her recent work on SMCHD1 and mechanisms of epigenetic silencing earned her the Genetics Society of AustralAsia Ross Crozier medal and the Lorne Genome Women in Science award. Her work has lead to projects investigating targeting SMCHD1 for the treatment of two different rare diseases that are caused by altered epigenetic state. Marnie jointly leads the Epigenetics and Development Division as a NHMRC Leadership fellow.