Prof Chambers’ research focuses on identification of mechanisms underlying the high rate of cardiovascular disease and diabetes in Asian populations and translational research to improve prevention and control of these major diseases. He has been closely involved in large-scale prospective population studies in Europe, South Asia and Singapore. These studies have contributed to the discovery of novel genetic and epigenetic pathways associated with coronary heart disease, type-2 diabetes, obesity, and related metabolic disturbances implicating new molecular pathways underlying these diseases.